The development landscape has changed significantly over the last few decades, becoming increasingly complex. Many of the issues we face today such as climate change, poverty and conflict, call for a new way of doing business. This guide shows leaders and development practitioners how to navigate this complexity and manage their initiatives/organizations successfully towards sustainable development impact. The Managing for Sustainable Development Impact (M4SDI) approach presented in this guide is an integrated, results-oriented management approach, which can be used across a range of sectors and domains in a variety of contexts, and aims to contribute towards the Sustainable Development Goals. It addresses some of the most pressing concerns, such as engaging primary stakeholders, designing effective strategies and related M&E, focusing on capacity development, and responding to change in a complex context.