Excerpt from National Institute of Arthritis and Musculoskeletal and Skin Diseases: Annual Reports; Intramural Research Programs; October 1, 1990 to October 1, 1990
The pattern of crossbridge formation between the thick and thin filaments was studied in the rigor state by using low salt, high ph conditions to dissociate the thick filaments and monitoring the detailed structural changes by edectronmicroscopy and X ray diffraction. In the part of the A-band that contains only thick filaments (the H-zone) the filaments dissociated mainly into three subfilaments. In the part of the A-band where thick and thin filaments interdigitate and actomyosin crossbridges are present, the thick filaments open to form hollow rings and then numerous subfilaments. This pattern of dissociation indicates that the thick filaments are made up of three parallel subfilaments, and that the crossbridges from each subfilament are shared by at least three of the adjacent actin filaments. (barbosa, Podolsky)
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